HL Chemistry IA 7점

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2018년 May IBDP 에 작성된 7점 받은 HL Chemistry IA 입니다. 4개월에 걸쳐 진행한 실험과 그 실험 결과, 그리고 그 결과들을 분석한 내용이 자세하게 작성됐습니다. 화학 IA 는 단순히 실험 설계와 실험 진행 뿐만 아니라 그 결과를 가지고 어떻게 분석해 내느냐가 핵심입니다. 그 분석 방법이 자세히 적혀있으니 참고하시면 도움이 될 것 같아 올립니다.
주제는 How does the concentration of KI solution affect the partition coefficient? 입니다.

 

[본문내용]

How does the concentration of KI solution affect the partition coefficient?

How does the change in concentration of KI solution (0.5M, 1.0M, 1.5M, 2.0M, 2.5M, 3.0M) affect the partition coefficient of Iodine between hexane and water at room temperature?

 

  1. Introduction

While taking a brain science course during the summer camp at a university, I learned that there is a certain drug dose for a drug to efficiently reach its target place in our bodies. Curious of how the medicine or drug dose is determined, I learned that the partition coefficient of drugs plays an important role in determining drug dose. Contrary to my expectation, drugs are not distributed evenly throughout a body after intake. This is because our cell membranes, which are consisted of lipid bilayers, allow only some solutes to pass while blocking others. Lipid-soluble (nonpolar) molecules can permeate the membrane, but the lipid bilayer repels water-soluble (polar) molecules.[1] Thus, lipophilicity [2], which is measured by partition coefficient, is a major structural factor governing pharmacodynamics of drugs. Different partition coefficients lead to different distribution patterns; hydrophobic drugs with high partition coefficients are mainly distributed to hydrophobic areas such as blood brain barrier (“Blood-Brain Barrier”), and hydrophilic drugs with low partition coefficient are distributed to aqueous areas such as blood serum (“Blood-Brain Barrier”)…

 

 

  • 총 페이지수: 15 pages
  • 과목: Chemistry
  • 주제: How does the concentration of KI solution affect the partition coefficient?
  • The file is in Word format. 
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HL Chemistry IA 7점

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